Polydimethylsiloxane Shelled Microbubbles for Biological Imaging, Drug Delivery, and Biodetection

Tech ID: 19696 / UC Case 2009-609-0

Brief Description

Researchers at the University of California, Irvine have developed novel polydimethylsiloxane shelled microbubbles that may be functionalized with a variety of ligands to selectively target treatment or diagnosis. These microbubbles may be used as a stand-alone application in biological applications such as medical imaging and drug delivery.

Technology Description

Researchers at the University of California, Irvine have developed novel polydimethylsiloxane shelled microbubbles that may be functionalized with a variety of ligands to selectively target treatment or diagnosis. In addition these microbubbles are stable up to a month. Unlike microbubbles that are currently available on the market, these microbubbles are more uniform and compact. Thus two-thirds less of these microbubbles are required to produce sharper images in patients.

Background

Medical applications of microbubbles include ultrasound contrast agents (UCAs), targeted UCAs, blood substitutes, targeted drug and gene delivery vehicles, and clot destruction. Treatment with microbubbles may be selectively targeted since the contents of the microbubble may be release with ultrasound. The stability of microbubbles is limited to a few minutes to a few hours due to the microbubbles’ gas exchange with the surrounding environment.

Suggested uses

These microbubbles may be used as a stand-alone application in biological applications such as medical imaging and drug delivery. Also these microbubbles may be used as a template material for creating microfluidic components with varying compositions.

Advantages

Two-thirds less of these microbubbles are required to produce sharper images in patients.

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Other Information

Keywords

microbubbles

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